Tetrahedron letters

A radical approach towards indolizidine 167B

MC Corvo, MMA Pereira

Index: Corvo, Marta C; Pereira, M.Manuela A Tetrahedron Letters, 2002 , vol. 43, # 3 p. 455 - 458

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Citation Number: 45

Abstract

The alkaloids (+)-and (−)-indolizidine 167B were synthesized via radical addition of a carbon radical to a chiral acrylamide. Further cyclization in the presence of BBr3, treatment with 'nickel boride'and stereospecific hydrogenation over palladium/carbon in acetic acid were other key steps in this synthesis.