Antimicrobial Agents and Chemotherapy 2012-11-01

In vitro activity of fluorescent dyes against asexual blood stages of Plasmodium falciparum.

Fanny Joanny, Jana Held, Benjamin Mordmüller

Index: Antimicrob. Agents Chemother. 56 , 5982-5985, (2012)

Full Text: HTML

Abstract

Many successful antimicrobial drugs originate from synthetic dyes. This paper reports the in vitro activity of 14 fluorescent dyes against Plasmodium falciparum. Five of these dyes (Hoechst 33342, MitoRed, DiOC(6), SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against two P. falciparum strains in the histidine-rich protein 2 drug sensitivity assay, while toxicity in HeLa cells is low. These dyes may be a starting point for developing new drugs against P. falciparum.

Related Compounds

  • 3,3'-Dihexyloxacar...
  • Mito Red

Related Articles:

The architecture and biological function of dual antibody-coated dendrimers: enhanced control of circulating tumor cells and their hetero-adhesion to endothelial cells for metastasis prevention.

2014-01-01

[Theranostics 4(12) , 1250-63, (2014)]

Centipedegrass extract induces apoptosis through the activation of caspases and the downregulation of PI3K/Akt and MAPK phosphorylation in leukemia cells.

2015-02-01

[Int. J. Mol. Med. 35(2) , 511-8, (2014)]

[Changes in polarization of myometrial cells plasma and internal mitochondrial membranes under calixarenes action as inhibitors of plasma membrane Na+, K+-ATPase].

[Ukr. Biokhim. Zh. 84(6) , 37-48, (2012)]

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth.

2014-10-30

[Oncotarget 5(20) , 9744-55, (2014)]

Design and optimization of lipid-modified poly(amidoamine) dendrimer coated iron oxide nanoparticles as probes for biomedical applications.

2015-04-28

[Nanoscale 7(16) , 7307-17, (2015)]

More Articles...