Chemical Communications 2014-10-18

Chemical modification of temoporfin--a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation.

Q Yu, E M Rodriguez, R Naccache, P Forgione, G Lamoureux, F Sanz-Rodriguez, D Scheglmann, J A Capobianco

Index: Chem. Commun. (Camb.) 50(81) , 12150-3, (2014)

Full Text: HTML

Abstract

LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.

Related Compounds

  • 4-Bromomethylbenzo...

Related Articles:

CO₂ controlled flocculation of microalgae using pH responsive cellulose nanocrystals.

2015-09-14

[Nanoscale 7 , 14413-21, (2015)]

Highly charged cellulose-based nanocrystals as flocculants for harvesting Chlorella vulgaris.

2015-10-01

[Bioresour. Technol. 194 , 270-5, (2015)]

5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.

2007-08-01

[Bioorg. Med. Chem. 15(15) , 5137-49, (2007)]

Synthesis and evaluation of the anti parasitic activity of aromatic nitro compounds.

2011-11-01

[Eur. J. Med. Chem. 46 , 5443-7, (2011)]

More Articles...