Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection.

Anne Beilvert, Roger Vassy, Emmanuelle Canet-Soulas, Olivier Rousseaux, Luc Picton, Didier Letourneur, Frédéric Chaubet

Index: Chem. Commun. (Camb.) 47 , 5506-5508, (2011)

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Abstract

This communication reports the synthesis, characterization and in vivo evaluation in mice of a new tri-tyrosine conjugated MR contrast agent, which may help to identify vulnerable plaques in atherosclerosis by targeting the lipid core.© The Royal Society of Chemistry 2011