Tetrahedron letters

N-Alkylation of amines with alcohols catalyzed by a Cp* Ir complex

K Fujita, Z Li, N Ozeki, R Yamaguchi

Index: Fujita, Ken-Ichi; Li, Zhenzi; Ozeki, Naohiro; Yamaguchi, Ryohei Tetrahedron Letters, 2003 , vol. 44, # 13 p. 2687 - 2690

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Citation Number: 208

Abstract

A new effective catalytic system consisting of [Cp* IrCl2] 2/K2CO3 (Cp*= pentamethylcyclopentadienyl) for the N-alkylation of primary amines with alcohols has been developed. As an example, the reaction of aniline with benzyl alcohol in the presence of [Cp* IrCl2] 2 (5.0 mol% Ir) and K2CO3 (5.0 mol%) in toluene at 110° C for 17 h gave benzylaniline in an isolated yield of 88%.

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