Bioorganic & Medicinal Chemistry Letters 2004-03-08

Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.

Nobuko Sakurai, Jiu-Hong Wu, Yutaka Sashida, Yoshihiro Mimaki, Tamotsu Nikaido, Kazuo Koike, Hideji Itokawa, Kuo-Hsiung Lee

Index: Bioorg. Med. Chem. Lett. 14(5) , 1329-32, (2004)

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Abstract

Actein (1), a tetracyclic triterpenoid from the rhizome of Cimicifuga racemosa (black cohosh), and 82 related triterpenoid and steroidal saponins isolated from higher plants were evaluated for anti-HIV activity as a continuing study to discover potential anti-AIDS agents from natural products. Actein showed potent activity and another twelve saponins showed moderate activity. The active compounds included two steroidal, seven tetracyclic triterpenoid, and four pentacyclic triterpenoid compounds.

Related Compounds

  • Actein

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