Tetrahedron: Asymmetry

Homochiral amine synthesis by baker's yeast resolution of a β-keto amide: 1-Phenylethylamine

T Hudlicky, G Gillman, C Andersen

Index: Hudlicky, T.; Gillman, Gene; Andersen, Catherine Tetrahedron: Asymmetry, 1992 , vol. 3, # 2 p. 281 - 286

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Citation Number: 18

Abstract

Abstract Preliminary investigation of the resolution potential of baker's yeast reduction of β- keto amides has been carried out with 1-phenylethylamine. Enantiomeric excess was determined by direct comparison of resolved enantiomers with derivatives prepared from commercially available (R)-(+)-1-phenylethylamine and was found to be 56–58.6% for the S enantiomer and 76–84.6% for the R enantiomer.