Cyclometallation of arylimines and nitrogen-containing heterocycles via room-temperature C-H bond activation with arene ruthenium(II) acetate complexes.

Bin Li, Thierry Roisnel, Christophe Darcel, Pierre H Dixneuf

Index: Dalton Trans. 36th ed., 41 , 10934-10937, (2012)

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Abstract

The reaction of [RuCl(2)(p-cymene)](2) with arylimines and 4 equiv. of KOAc in methanol at room temperature produces stable (N^C)-cyclometallated ruthenium(II) complexes via C-H bond activation/deprotonation. This method can be applied also to nitrogen-containing molecules: N-phenylpyrazole, 2-phenyl-2-oxazoline and benzo[h]quinoline. N-Phenyl-pyrazole, [RuCl(2)(p-cymene)](2) and diphenylacetylene directly lead to alkyne insertion into the metallacycle C-Ru bond.