Journal of Medicinal Chemistry

A Study of the Inhibitory Effect of Various Hydrazides on Monoamine Oxidase in vitro and in vivo

J Szmuszkovicz, ME Greig

Index: Szmuszkovicz,J.; Greig,M.E. Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 4, p. 259 - 296

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Citation Number: 12

Abstract

The work described in this paper was initiated by an observation that a by-product from a somewhat unusual chemical reaction showed some unexpected pharmacological activity. During an attempted preparation of 2-methyl-3-indoleglyoxylic acid hydrazide, ethyl 2- methyl-3-indoleglyoxylate (I)* was subjected to hydrazinolysis with hydrazine hydrate.