Borrowing hydrogen: iridium-catalysed reactions for the formation of C-C bonds from alcohols.

Phillip J Black, Gerta Cami-Kobeci, Michael G Edwards, Paul A Slatford, Michael K Whittlesey, Jonathan M J Williams

Index: Org. Biomol. Chem. 4(1) , 116-25, (2006)

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Abstract

Alcohols have been employed as substrates for C-C bond-forming reactions which involve initial activation by the temporary removal of hydrogen to form an aldehyde. The intermediate aldehyde is converted into an alkene via a Horner-Wadsworth-Emmons reaction, nitroaldol and aldol reactions. The 'borrowed hydrogen' is then returned to the alkene to form a C-C bond.