Synthesis

Indium mediated reduction of nitro and azide groups in the presence of HCl in aqueous media

JG Lee, KI Choi, HY Koh, Y Kim, Y Kang, YS Cho

Index: Lee, Jung Gyu; Choi, Kyung Il; Koh, Hun Yeong; Kim, Youseung; Kang, Yonghan; Cho, Yong Seo Synthesis, 2001 , # 1 p. 81 - 84

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Citation Number: 42

Abstract

Abstract: Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF successfully provided the corresponding amine in high to quantitative yields. Under the same reaction conditions, selective reduction of azide and nitro group in the presence of vinyl group could be accomplished. Key words: nitro compounds, azides, reductions, indium, amines

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