Strahlentherapie und Onkologie 1986-01-01

[Organ distribution of ruthenocenyl biogenic amine derivatives--radiodiagnostic agents for the adrenals and ovaries?].

M Wenzel, P Asindraza

Index: Strahlenther. Onkol. 162(1) , 51-6, (1986)

Full Text: HTML

Abstract

The organ distribution of 103Ru labelled ruthenocenyl derivatives of tyramine, histamine, benzylamine, phenylethylamine and homoveratrylamine were measured in rats. The derivatives of tyramine, histamine and benzylamine showed a high affinity for the adrenal and ovar. Adrenal/muscle ratios up to 2000:1 were gained but only if the dose was administered i.v. and was below 0.1 mumol/kg. The ruthenocenyl derivatives of tyramine labelled with 103Ru in the ruthenocene moiety or with 14C in the tyramine moiety showed a parallel distribution pattern but completely different from the distribution of 103RuCl3. This indicates that the tyramine derivatives are not destroyed in the body yielding Ru-ions. The advantages of the ruthenocenyl derivatives in comparison with the known amphetamine derivatives labelled with radioactive iodine are discussed.

Related Compounds

  • Di-1,3-cyclopentad...

Related Articles:

Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior.

2005-04-21

[J. Med. Chem. 48 , 2814-21, (2005)]

Group 8 metallocenes as bulky functional groups in glucopyranosides.

2013-01-10

[Carbohydr. Res. 365 , 26-31, (2013)]

Structural investigation of the interactions of biotinylruthenocene with avidin.

2013-06-25

[Chem. Biol. Interact. 204(1) , 6-12, (2013)]

Adrenal-affinity of ruthenocenyl-derivatives of biogenic amines

1985-01-01

[Int. J. Nucl. Med. Biol. 12(1) , 1-2, (1985)]

[Enzymatic hydroxylation of ruthenocene and osmocene by liver microsomes].

1982-01-01

[Z. Naturforsch., C, J. Biosci. 37(1-2) , 136-8, (1982)]

More Articles...