Highly efficient Suzuki–Miyaura coupling of heterocyclic substrates through rational reaction design

CA Fleckenstein, H Plenio

Index: Fleckenstein, Christoph A.; Plenio, Herbert Chemistry - A European Journal, 2008 , vol. 14, # 14 p. 4267 - 4279

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Citation Number: 88

Abstract

Abstract A dicyclohexyl (2-sulfo-9-(3-(4-sulfophenyl) propyl)-9H-fluoren-9-yl) phosphonium salt was synthesized in 64% overall yield in three steps from simple commercially available starting materials. The highly water-soluble catalyst obtained from the corresponding phosphine and [Na 2 PdCl 4] enabled the Suzuki coupling of a broad variety of N-and S- heterocyclic substrates. Chloropyridines (-quinolines) and aryl chlorides were coupled ...