Tetrahedron letters

A mild and efficient biomimetic synthesis of α-hydroxymethylarylketones from oxiranes in the presence of β-cyclodextrin and NBS in water

MA Reddy, N Bhanumathi, KR Rao

Index: Arjun Reddy; Bhanumathi; Rama Rao Tetrahedron Letters, 2002 , vol. 43, # 17 p. 3237 - 3238

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Citation Number: 28

Abstract

α-Hydroxymethylarylketones can be synthesized in good yields from easily accessible epoxides in the presence of β-cyclodextrin and NBS in water. This method is a direct, one- pot, synthesis under mild conditions using water as solvent and has many advantages over existing methodologies.

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