Tetrahedron letters

Microwave-assisted synthesis of α-hydroxy ketone and α-diketone and pyrazine derivatives from α-halo and α, α′-dibromo ketone

T Utsukihara, H Nakamura, M Watanabe, CA Horiuchi

Index: Utsukihara, Takamitsu; Nakamura, Hiroaki; Watanabe, Masashige; Akira Horiuchi Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9359 - 9364

Full Text: HTML

Citation Number: 24

Abstract

A novel reaction of α-halo ketone (α-bromo and α-chloro ketone) with irradiation under microwave gave the corresponding α-hydroxyketone and pyrazine derivative in good yields. In the case of α, α′-dibromo ketone, α-diketone was obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxyketone, α-diketone, α-chloro ketone and pyrazine derivative.

Related Articles:

A mild and efficient biomimetic synthesis of α-hydroxymethylarylketones from oxiranes in the presence of β-cyclodextrin and NBS in water

[Arjun Reddy; Bhanumathi; Rama Rao Tetrahedron Letters, 2002 , vol. 43, # 17 p. 3237 - 3238]

Chemo-enzymatic preparation of hydroxymethyl ketones

[Paizs, Csaba; Tosa, Monica; Majdik, Cornelia; Bodai, Viktoria; Novak, Lajos; Irimie, Florin-Dan; Poppe, Laszlo Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 21 p. 2400 - 2402]

Catalytic and Chemoselective Oxidation of Activated Alcohols and Direct Conversion of Diols to Lactones with In Situ??Generated Bis??IBX Catalyst

[Seth, Saona; Jhulki, Samik; Moorthy, Jarugu Narasimha European Journal of Organic Chemistry, 2013 , # 12 p. 2445 - 2452]

Direct α-hydroxylation of aryl ketones using a hypervalent Iodine (III) sulfonate

[Huang; Hou; Wang; Chen Organic Preparations and Procedures International, 2006 , vol. 38, # 5 p. 473 - 476]

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases

[Waszkuc, Wieslaw; Janecki, Tomasz; Bodalski, Ryszard Synthesis, 1984 , # 12 p. 1025 - 1027]

More Articles...