Exploring the UDP pocket of LpxC through amino acid analogs

MR Hale, P Hill, S Lahiri, MD Miller, P Ross…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 8 p. 2362 - 2367

Full Text: HTML

Citation Number: 7

Abstract

... Bioorganic & Medicinal Chemistry Letters. Volume 23, Issue 8, 15 April 2013, Pages 2362–2367. Cover image Cover image. ... The inhibitors discussed in this Letter focus on diversity in the UDP pocket through R 1 variations, we then studied how they impact potency. ...

Related Articles:

Aqueous-phase, palladium-catalyzed cross-coupling of aryl bromides under mild conditions, using water-soluble, sterically demanding alkylphosphines

[DeVasher, Rebecca B.; Moore, Lucas R.; Shaughnessy, Kevin H. Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 7919 - 7927]

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

[Ritzen, Andreas; Sindet, Rikke; Hentzer, Morten; Svendsen, Nannette; Brodbeck, Robbin M.; Bundgaard, Christoffer Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 12 p. 3275 - 3278]

A Simple and Efficient Copper??Free Catalytic System Based on a Palladacycle for the Arylation of Alkynes

[Consorti, Crestina S.; Flores, Fabricio R.; Rominger, Frank; Dupont, Jairton Advanced Synthesis and Catalysis, 2006 , vol. 348, # 1-2 p. 133 - 141]

Piperazine-2, 3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors

[Irvine, Mark W.; Costa, Blaise M.; Dlaboga, Daniel; Culley, Georgia R.; Hulse, Richard; Scholefield, Caroline L.; Atlason, Palmi; Fang, Guangyu; Eaves, Richard; Morley, Richard; Mayo-Martin, Maria B.; Amici, Mascia; Bortolotto, Zuner A.; Donaldson, Lucy; Collingridge, Graham L.; Molnar, Elek; Monaghan, Daniel T.; Jane, David E. Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 327 - 341]

General catalysts for the Suzuki–Miyaura and Sonogashira coupling reactions of aryl chlorides and for the coupling of challenging substrate combinations in water

[Angewandte Chemie - International Edition, , vol. 44, # 38 p. 6173 - 6177]

More Articles...