Journal of Fluorescence 2012-07-01

Fluorometric determination of bopindolol and celiprolol in pharmaceutical preparations and biological fluids.

F Belal, M Sharaf El-Din, F Aly, M Hefnawy, M El-Awady

Index: J. Fluoresc. 22(4) , 1141-50, (2012)

Full Text: HTML

Abstract

Two sensitive fluorometric methods were developed for the determination of both bopindolol malonate (BOP) and celiprolol HCl (CLP) based on measuring their native fluorescence in methanol and acetonitrile, respectively. For BOP, the fluorescence was measured at 316 nm after excitation at 278 nm. The proposed method was successfully applied to the assay of commercial tablets as well as content uniformity testing. For CLP, the fluorescence was enhanced by the addition of carboxymethylcellulose solution and measured at 455 nm after excitation at 339 nm. The method was successfully applied to the analysis of CLP in tablets and biological fluids. In both methods, interference likely to be introduced from co-formulated, co-administered, or chemically related drugs was studied. The results were statistically compared with those obtained by reference methods and were found to be in good agreement.

Related Compounds

  • Celiprolol HCl
  • Pindolol

Related Articles:

Highly sensitive transient isotachophoresis sample stacking coupling with capillary electrophoresis-amperometric detection for analysis of doping substances

2010-01-01

[Talanta 81(4-5) , 1288-94, (2010)]

Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis.

2008-06-01

[Electrophoresis 29(11) , 2321-9, (2008)]

Direct determination of celiprolol in human urine using on-line coupled ITP-CZE method with fiber-based DAD.

2008-11-01

[Electrophoresis 29(22) , 4561-7, (2008)]

Celiprolol, a selective beta1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction.

2007-04-01

[Circ. J. 71(4) , 574-9, (2007)]

Effects of itraconazole, dexamethasone and naringin on the pharmacokinetics of nadolol in rats.

2013-01-01

[Drug Metab. Pharmacokinet. 28(4) , 356-61, (2013)]

More Articles...