Folia Microbiologica 1989-01-01

Microbial transformation of semisynthetic derivatives of daunomycinone modified in ring A.

V Prikrylova, J Jizba, M Blumauerova, J Huk, P Sedmera

Index: Folia Microbiol. (Praha) 34(5) , 459-62, (1989)

Full Text: HTML

Abstract

Semisynthetic derivatives of daunomycinone with 7,9-isopropylacetal, 7-O-methyl, 7-O-(4-penten-2-yl), and 7-O-(2-hydroxyethyl) substituents were converted by Streptomyces peucetius var. caesius (an adriamycin-blocked mutant) into 7-deoxy-13-dihydrodaunomycinone, while daunomycinone was transformed into 13-dihydrodaunomycinone (predominantly) and 7-deoxy-13-dihydrodaunomycinone. S. coeruleorubidus mutants 24-74 (accumulating aclavinone derivatives instead of daunomycin and related compounds) and 96-85 (producing no anthracycline substances), and S. aureofaciens B-96 (a tetracycline-blocked mutant) transformed the above substrates into the corresponding 13-dihydro derivatives, with the exception of 7,9-isopropylacetal daunomycinone which remained intact. 7-O-Propyn-1-yl daunomycinone was not transformed by any of the strains used under the conditions.

Related Compounds

  • Daunomycinone

Related Articles:

Semiquinone free radical formation by daunorubicin aglycone incorporated into the cellular membranes of intact Chinese hamster ovary cells.

1996-01-01

[Free Radic. Res. 24(1) , 9-18, (1996)]

Biotransformation of aklanonic acid by blocked mutants of anthracycline-producing strains of Streptomyces galilaeus and Streptomyces peucetius.

1986-01-01

[J. Basic Microbiol. 26(4) , 249-55, (1986)]

Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone.

1985-12-01

[J. Antibiot. 38(12) , 1714-8, (1985)]

Synthesis and cytotoxic activity of a new potent daunomycinone derivative.

2002-12-16

[Bioorg. Med. Chem. Lett. 12(24) , 3505-7, (2002)]

Method for analysis, and distribution profile, of covalently-linked ferritin-daunorubicin conjugate in the blood of trypanosome-infected mice.

1992-01-01

[J. Pharm. Pharmacol. 44(1) , 48-51, (1992)]

More Articles...