Comparison of the efficacy of three progestins in the treatment of simple endometrial hyperplasia without atypia.

Ozlem Ozdegirmenci, Fulya Kayikcioglu, Ulku Bozkurt, Mehmet Akif Akgul, Ali Haberal

Index: Gynecol. Obstet. Invest. 72(1) , 10-4, (2011)

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Abstract

To evaluate the treatment of endometrial hyperplasia (EH) with different progestins.Eighty-two women with simple EH without atypia were included. Patients were offered oral progestagens and were randomized to one of three options for 3 months: medroxyprogesterone acetate (MPA, 10 mg/day), lynestrenol (LYN, 15 mg/day) and norethisterone (NET, 15 mg/day) for 10 days per cycle. Patients were reevaluated after treatment. Women diagnosed with proliferative and nonatypical EH at the second curettage were offered the same progestins for another 3 months. The primary outcome of the study was the proportion of women requiring further treatment.Of the 82 women, 46 (56.1%) received MPA (23.2%), LYN (13.4%) and NET (19.5%) therapy for another 3 months at the end of the first 3 months of treatment. The patients receiving MPA showed resolution in 36.7% of the cases versus 37% in the NET group. The highest resolution rate (56%) was observed in the LYN group, although there was no statistically significant difference between progestins regarding the proportion of women requiring further treatment (χ(2) = 2.608; p = 0.271).It seems that the efficacies of oral progestins are similar at these dosages in simple EH without atypia.Copyright © 2011 S. Karger AG, Basel.