Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

…, M Izumi, N Baba, K Kawazu, S Nakajima

Index: Takaishi, Kazuto; Izumi, Minoru; Baba, Naomichi; Kawazu, Kazuyoshi; Nakajima, Shuhei Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5614 - 5617

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Citation Number: 12

Abstract

We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

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