Journal of AOAC International 1993-01-01

Stability-indicating proton nuclear magnetic resonance spectroscopic assay method for furosemide in tablets and injections.

G M Hanna, C A Lau-Cam

Index: J. AOAC Int. 76(3) , 526-30, (1993)

Full Text: HTML

Abstract

A simple, specific, and accurate proton nuclear magnetic resonance (1H-NMR) spectroscopic method has been developed for the identification and assay of furosemide and its degradation product, 4-chloro-5-sulfamoylanthranilic acid (CSA), in tablets and injections. Dissolution of the sample in D2O-NaOD resulted in a solution yielding the required separation among the resonance signals of furosemide, CSA, and tert-butyl alcohol, the internal standard. The mean +/- SD recovery values of furosemide and CSA from 10 synthetic formulations were 99.6 +/- 0.8 and 98.9 +/- 1.7%, respectively. Commercial tablets (6 lots) and injections (5 lots) of furosemide were assayed by the proposed method and found to contain 53.1-99.8% furosemide and 0.3-45.2% CSA.

Related Compounds

  • 4-Chloro-5-sulfamo...

Related Articles:

The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products.

1981-09-01

[Acta Pharmacol. Toxicol. (Copenh.) 49(3) , 223-9, (1981)]

The binding of furosemide to serum proteins in elderly patients: displacing effect of phenprocoumon.

1980-09-01

[Acta Pharmacol. Toxicol. (Copenh.) 47(3) , 202-7, (1980)]

Furosemide accelerates gentamicin accumulation in cultured renal cells (LLC-PK1 cells).

1989-01-01

[Nephron 53(2) , 138-41, (1989)]

Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay.

1980-01-01

[Drug Metab. Dispos. 8(5) , 337-42, (1980)]

The urinary excretion of frusemide and its metabolites by kidney transplant patients.

1987-01-01

[Eur. J. Clin. Pharmacol. 32(3) , 313-5, (1987)]

More Articles...