Journal of Organic Chemistry 2002-02-22

An improved synthesis of a trifurcated newkome-type monomer and orthogonally protected two-generation dendrons.

Claudia M Cardona, Robert E Gawley

Index: J. Org. Chem. 67(4) , 1411-3, (2002)

Full Text: HTML

Abstract

The one-step synthesis of amino-polyether tri-tert-butyl ester monomer 2, by condensation of TRIS with tert-butyl acrylate, is reported. The nitrogen of the monomer can be protected with a Cbz group; subsequent removal of the tert-butyl esters with formic acid affords a triacid that is coupled to three monomers to afford an orthogonally protected two-generation, trifurcated polyether-polyamide dendron. The Cbz protecting group may be removed from the second-generation dendron without disturbing the tert-butyl esters of the periphery.

Related Compounds

  • Benzyl chloroforma...

Related Articles:

Polymeric micelles for pH-responsive delivery of cisplatin.

2014-08-01

[J. Drug Target. 22(7) , 629-37, (2014)]

Ames Salmonella/mammalian-microsome testing of peptides and peptide synthesis reagents.

1986-01-01

[Mutat. Res. 170(1-2) , 23-9, (1986)]

Untargeted metabolomics in doping control: detection of new markers of testosterone misuse by ultrahigh performance liquid chromatography coupled to high-resolution mass spectrometry.

2015-08-18

[Anal. Chem. 87 , 8373-80, (2015)]

Curtius rearrangement of aromatic carboxylic acids to access protected anilines and aromatic ureas.

2006-12-07

[Org. Lett. 8 , 5717, (2006)]

Synthesis, colon-targeted studies and pharmacological evaluation of an anti-ulcerative colitis drug 4-Aminosalicylic acid-β-O-glucoside.

2016-01-27

[Eur. J. Med. Chem. 108 , 486-94, (2016)]

More Articles...