Benzofurazanyl-and benzofuroxanyl-1, 4-dihydropyridines: synthesis, structure and calcium entry blocker activity

AM Gasco, G Ermondi, R Fruttero, A Gasco

Index: Gasco; Ermondi; Fruttero European Journal of Medicinal Chemistry, 1996 , vol. 31, # 1 p. 3 - 10

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Citation Number: 30

Abstract

The synthesis, structural characterization and calcium blocking activity of a series of benzofurazanyl-1, 4-dihydropyridines (18 and 19) and benzofuroxanyl analogues (20 and 21) are reported. 1H-NMR showed that all the benzofuroxan derivatives exist in solution as tautomeric mixtures. The predominant tautomeric form in solution of the derivative 20 (dimethyl 1, 4-dihydro-2, 6-dimethyl-4-(4-benzofuroxanyl)-3, 5-pyridinedicarboxylate) is ...

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