Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues
IN Redwan, T Ljungdahl, M Grøtli
Index: Redwan, Itedale Namro; Ljungdahl, Thomas; Grotli, Morten Tetrahedron, 2012 , vol. 68, # 5 p. 1507 - 1514
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Citation Number: 4
Abstract
Aminoacyl-tRNA synthetases (aaRSs) constitute a family of enzymes that transfer amino acids to their corresponding tRNA molecules to form aminoacyl-tRNAs and have been validated as potential drug targets. Sulfamoyloxy-linked aminoacyl-AMP analogues are potent inhibitors of aaRSs. In this article, we report the synthesis of several new sulfamoyl analogues of aa-AMP that up to now have been difficult or even impossible to prepare ...
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