Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moiety

…, M Berettoni, M Bigioni, M Binaschi, A Cipollone…

Index: Animati, Fabio; Berettoni, Marco; Bigioni, Mario; Binaschi, Monica; Cipollone, Amalia; Irrissuto, Clelia; Nardelli, Federica; Olivieri, Lauso Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5013 - 5017

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Citation Number: 7

Abstract

Glycosylated indolocarbazoles related to the antibiotic rebeccamycin represent an important class of antitumour drugs. In the course of our structure–activity relationship studies, new rebeccamycin analogues modified at the imide moiety were synthesised. The antiproliferative activity of the compounds was evaluated on three human cancer cell lines, A2780 (ovarian cancer), H460 (lung cancer), and GLC4 (small-cell lung cancer). The in ...