2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.

S S Shin, M S Noh, Y J Byun, J K Choi, J Y Kim, K M Lim, J Y Ha, J K Kim, C H Lee, S Chung

Index: Bioorg. Med. Chem. Lett. 11(2) , 165-8, (2001)

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Abstract

A series of 2,2-dimethyl-5-[4-(methylsulfonyl)phenyl]-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).