A flow-based synthesis of 2-aminoadamantane-2-carboxylic acid

C Battilocchio, IR Baxendale, M Biava…

Index: Battilocchio, Claudio; Baxendale, Ian R.; Biava, Mariangela; Kitching, Matthew O.; Ley, Steven V. Organic Process Research and Development, 2012 , vol. 16, # 5 p. 798 - 810

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Citation Number: 35

Abstract

The development of a new, high-yielding, scalable and safe process for the preparation of 2- aminoadamantane-2-carboxylic acid (1) is described. This geminal, functionalized achiral amino acid has been reported to possess interesting biological activity as a transport mediator due to its unique physiochemical properties. We report herein on the use of various mesoreactor flow devices to expedite the lab-scale synthesis of this molecule by ...