Preparation and antibacterial evaluation of decarboxylated fluoroquinolones

ST Nguyen, X Ding, MM Butler, TF Tashjian…

Index: Nguyen, Son T.; Ding, Xiaoyuan; Butler, Michelle M.; Tashjian, Tommy F.; Peet, Norton P.; Bowlin, Terry L. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5961 - 5963

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Citation Number: 6

Abstract

Decarboxylated ciprofloxacin (3) has been reported in the literature to have antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus subtilis, Enterobacter cloacae, Serratia marcescens and especially potent activity against Escherichia coli. Herein, we report our syntheses of 3 and five additional decarboxylated fluoroquinolones (FQs). We have re-evaluated the antibacterial activity of ...