Synthesis of 5??Substituted 1H??Tetrazoles from Nitriles and Hydrazoic Acid by Using a Safe and Scalable High??Temperature Microreactor Approach

B Gutmann, JP Roduit, D Roberge…

Index: Gutmann, Bernhard; Roduit, Jean-Paul; Kappe, C. Oliver; Roberge, Dominique Angewandte Chemie - International Edition, 2010 , vol. 49, # 39 p. 7101 - 7105

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Citation Number: 113

Abstract

Interest in tetrazole chemistry over the past few years has been increasing rapidly, mainly as a result of the role played by this heterocyclic functionality in medicinal chemistry as a metabolically stable surrogate for carboxylic acid functionalities.[1] Additional important applications for tetrazoles are found in coordination chemistry, materials science, and as intermediates in a variety of synthetic transformations.[2] The most common synthetic ...