European Journal of Medicinal Chemistry 2003-01-01

Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring.

Angeles Castro, José M Miguel del Corral, Marina Gordaliza, Concepción Grande, Antonia Gómez-Zurita, Dolores García-Grávalos, Arturo San Feliciano, Angeles Castro, José M.Miguel del Corral, Marina Gordaliza, Concepción Grande, Antonia Gómez-Zurita, Dolores Garcı́a-Grávalos, Arturo San Feliciano

Index: Eur. J. Med. Chem. 38(1) , 65-74, (2003)

Full Text: HTML

Abstract

Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.Copyright 2002 Editions scienctifiques et médicales Elsevier SAS

Related Compounds

  • 1,3-Benzodioxole

Related Articles:

Smooth photocatalytic preparation of 2-substituted 1,3-benzodioxoles.

2011-01-10

[Chemistry 17(2) , 572-9, (2011)]

Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501.

1995-02-01

[Toxicol. Lett. 76(1) , 39-45, (1995)]

Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme.

1997-06-01

[Lipids 32(6) , 605-10, (1997)]

A natural component as coinitiator for unfilled dental resin composites.

2007-07-01

[J. Biomed. Mater. Res. B. Appl. Biomater. 82(1) , 44-50, (2007)]

A spectrophotometric assay for the detection of fungal peroxygenases.

2012-02-01

[Anal. Biochem. 421(1) , 327-9, (2012)]

More Articles...