Organic Letters 2008-10-16

The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical properties.

Raj Kumar, Ravi K Ujjinamatada, Ramachandra S Hosmane

Index: Org. Lett. 10(20) , 4681-4, (2008)

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Abstract

The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links.

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