Biometrics 1999-12-01

On the use of historical control data for trend test in carcinogenicity studies.

J Sun

Index: Biometrics 55(4) , 1273-6, (1999)

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Abstract

Historical control data are often available in carcinogenicity studies and are included for testing dose effects in current studies. A new method is developed for incorporating the historical control information into a dose effect test. The method generalizes the test procedures proposed by Tarone (1982, Biometrics 38, 215-220) and Ibrahim and Ryan (1996, Biometrics 52, 1478-1485) by taking into account the variation resulting from parameter estimation based on historical data. Two examples are discussed for illustrating the proposed method.

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