Journal of the American Chemical Society

Potential Purine Antagonists. XV. Preparation of Some 6, 8-Disubstituted Purines1

RK Robins

Index: Robins Journal of the American Chemical Society, 1958 , vol. 80, p. 6671,6675

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Citation Number: 73

Abstract

SCH, XXXV aminopurine could not be prepared by coupling of 2, 4- dichlorobenzenediazonium chloride with adenine or hypoxanthine followed by the usual sodium hydrosulfite reduction to introduce the 8-anlino group. This reaction however is quite successful for the introduction of the 8-amino group into xanthine, 3 guanine3 and isoguanine. 14 In the search for a new method of preparing 6-substituted-8-aminopurines ...