A photolabile protection strategy for terminal alkynes

TA Gschneidtner, K Moth-Poulsen

Index: Gschneidtner, Tina A.; Moth-Poulsen, Kasper Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5426 - 5429

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Citation Number: 3

Abstract

Abstract We present a strategy for photolabile protection of terminal alkynes. Several photo- caged alcohols were synthesized via mild copper (II)-catalyzed substitution between tertiary propargylic alcohols and 2-nitrobenzyl alcohol to build up robust, base stable o-nitrobenzyl (NB) photo-cleavable compounds. We compare the new photolabile protecting group with the commonly used alkyne protecting group, 2-methyl-3-butyn-2-ol and the results show ...