Synthesis and Structure??Activity Relationships of A Novel Class of Dithiocarbamic Acid Esters as Anticancer Agent

X Hou, Z Ge, T Wang, W Guo, J Wu, J Cui…

Index: Hou, Xueling; Ge, Zemei; Wang, Tingmin; Guo, Wei; Wu, Jun; Cui, Jingrong; Lai, Chingsan; Li, Runtao Archiv der Pharmazie, 2011 , vol. 344, # 5 p. 320 - 332

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Citation Number: 13

Abstract

Abstract Based on a novel lead compound 4-methylpiperazine-1-carbodithioic acid 3-cyano- 3, 3-diphenylpropyl ester 1, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their in-vitro anticancer activities on four to six different cell lines at three different concentrations. Most of the tested compounds could selectively inhibit the growth of HL-60 and Bel-7402 cell lines at a medium concentration. ...

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