Facile synthesis of acyl-substituted lactone derivatives from acyclic keto esters

RD Miller, GN Fickes

Index: Miller, Robert D.; Fickes, Garry N. Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2375 - 2377

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Citation Number: 5

Abstract

4 (85) of ethyl levulinate, which yields a mixture of both 3 and 4, the chemoselectivity is maintained, but the reaction is less regioselective. In spite of this, the internal olefin 4 is still the major component of the product mixture. l Since trimethylsilyl enol ethers are extremely useful synthetic reagentsY2 we felt that derivatives such as 1-4 which contain multiple but differentiated chemical functionality offered considerable synthetic potential. In this