Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers

…, F Calard, L Sanguinet, E Levillain, P Richomme…

Index: Sero, Luc; Calard, Francois; Sanguinet, Lionel; Levillain, Eric; Richomme, Pascal; Seraphin, Denis; Derbre, Severine Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6716 - 6720

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Abstract

Advanced glycation end-products, namely AGEs, are involved in the pathogenesis of numerous diseases. If AGEs inhibitors are well-known, only few products are described as compounds able to destroy those deleterious products. In this work, we describe naphthoic acid derivatives, particularly 1-(naphthalen-1-yl) propane-1, 2-dione 9, allowing the simple and rapid detection of AGEs breakers using a 96-well microplate fluorescence assay. ...