A chiral total synthesis of compactin

M Hirama, M Uei

Index: Hirama; Uei Journal of the American Chemical Society, 1982 , vol. 104, # 15 p. 4251 - 4253

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Citation Number: 103

Abstract

P (OMe) ZOHC w OB z I 5 lseqment A) 6 (segment B) reaction, because the asymmetric center at C13 was expected to control the approach of the dienophile from a single diastereomeric face by steric and stereoelectronic interactions.'(3) Wadsworth-Emmons coupling of the optically active segments A (5) and B (6) was envisioned for the expeditious preparation of the requisite (E, E, E)-trienone 4.(4) Development of an asymmetric ...