New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle

…, A Chidichimo, JJ Cazzulo, C Olea-Azar…

Index: Porcal, Williams; Hernandez, Paola; Boiani, Lucia; Boiani, Mariana; Ferreira, Ana; Chidichimo, Agustina; Cazzulo, Juan J.; Olea-Azar, Claudio; Gonzalez, Mercedes; Cerecetto, Hugo Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6995 - 7004

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Citation Number: 41

Abstract

Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically evaluated displaying remarkable in vitro activity against different strains of T. cruzi. Unspecific cytotoxicity was evaluated using mouse macrophages, displaying isothiosemicarbazone 10 and thiosemicarbazone 12 ...