Facile aza-Michael additions of uracil derivatives to acrylates

S Zhou, M Xu, S Ye, D Li, J Xu, P Mao…

Index: Zhou, Shuguang; Xu, Mingxia; Ye, Siyu; Li, Dashuai; Xu, Jing; Mao, Pei; Xiong, Jing Journal of Chemical Research, 2012 , vol. 36, # 2 p. 114 - 117

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Citation Number: 2

Abstract

24 Aza-Michael adducts were synthesised in moderate to excellent yields by the addition of 5-substituted uracils to acrylates with ethylamine as a catalyst. Many of the adducts were obtained in almost quantitive yield without column chromatography. The procedure provideded an efficient approach to the synthesis of N-1 uracil adducts using acrylates as acceptors. The structures of the compounds were determined by 1H NMR, 13C NMR, ...