Design, synthesis, and biological activity of hybrid compounds between uramustine and DNA minor groove binder distamycin A

…, AE Guadix, MJ Pineda de las Infantas…

Index: Baraldi, Pier Giovanni; Romagnoli, Romeo; Guadix, Antonio Entrena; Pineda de las Infantas, Maria Jose; Gallo, Miguel Angel; Espinosa, Antonio; Martinez, Alberto; Bingham, John P.; Hartley, John A. Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3630 - 3638

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Citation Number: 51

Abstract

The design, synthesis, characterization, DNA binding properties, and cytotoxic activity of a novel series of hybrids, namely, a molecular combination of the natural antibiotic distamycin A and the antineoplastic agent uramustine, are reported, and the structure-activity relationships are discussed. This homologous series 29-34 consisted of the minor groove binder distamycin A joined to uramustine (uracil mustard) by suitable aliphatic carboxylic ...