Zirconium??Mediated Coupling Reactions of Amines and Enol or Allyl Ethers: Synthesis of Allyl??and Homoallylamines

…, F Rodriguez, L Álvarez??Rodrigo…

Index: Barluenga, Jose; Rodriguez, Felix; Alvarez-Rodrigo, Lucia; Zapico, Jose M.; Fananas, Francisco J. Chemistry - A European Journal, 2004 , vol. 10, # 1 p. 109 - 116

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Citation Number: 29

Abstract

Abstract An easy and efficient zirconium-mediated synthesis of allylamines from simple amines and enol ethers is described. This strategy also allows the synthesis of amino alcohol derivatives containing a Z double bond in their structure when 2, 3-dihydrofuran is used. Simple conventional modification of these amino alcohols leads to 2-substituted piperidine derivatives. By applying this approach, a formal total synthesis of the alkaloid ...

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