Medicinal Chemistry Research

Development of amino acid conjugated sulfonamides as potent antiulcer agent

SP Sahoo, BB Subudhi

Index: Sahoo, Shakti Prasanna; Subudhi, Bharat Bhusan Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3039 - 3048

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Citation Number: 2

Abstract

Abstract A series of 2-{[(4-methylphenyl) sulfonyl] amino}-3-sulfanylpropanoic acid (1a) and its analogs 1b–j have been synthesized. These compounds were screened for their in vivo efficacy in pyloric ligation model. Compounds 1a and 1b with higher antiulcer potential were further screened in other gastric models to explore the mode of antiulcer action. To further understand the mode of action, in vitro inhibition of H+/K+ ATPase activity in gastric ...