Tetrahedron Letters

Calcite and fluorite as catalyst for the Knoevenagel condensation of malononitrile and methyl cyanoacetate under solvent-free conditions

S Wada, H Suzuki

Index: Wada, Shinobu; Suzuki, Hitomi Tetrahedron Letters, 2003 , vol. 44, # 2 p. 399 - 401

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Citation Number: 85

Abstract

The Knövenagel condensation has been an important tool for constructing the α,β-unsaturated structure unit from a carbonyl and an active methylene components. 1., and The reaction is usually carried out in the presence of a weak base, which includes aliphatic amines such as ethylenediamine and piperidine or corresponding ammonium salts, 2., and amino acids such as glycine and β-alanine, 3., and and potassium fluoride. 4 The reaction is strongly dependent on ...