Science 1987-08-21

A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

L J Suva, G A Winslow, R E Wettenhall, R G Hammonds, J M Moseley, H Diefenbach-Jagger, C P Rodda, B E Kemp, H Rodriguez, E Y Chen

Index: Science 237 , 893, (1987)

Full Text: HTML

Abstract

Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney. We report here the isolation of full-length complementary DNA clones of a putative hypercalcemia factor, and the expression from the cloned DNA of the active protein in mammalian cells. The clones encode a prepro peptide of 36 amino acids and a mature protein of 141 amino acids that has significant homology with parathyroid hormone in the amino-terminal region. This previously unrecognized hormone may be important in normal as well as abnormal calcium metabolism.

Related Compounds

  • pTH-Related Prot...

Related Articles:

Parathyroid hormone-related peptide stimulates proliferation of highly tumorigenic human SV40-immortalized breast epithelial cells.

2000-11-01

[J. Bone Miner Res. 15 , 2129-2139, (2000)]

Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo.

1997-08-01

[Cancer Res. 57 , 3194-3199, (1997)]

Effects of transforming growth factor-alpha on parathyroid hormone- and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro.

1991-10-01

[Domest. Anim. Endocrinol. 8 , 499-507, (1991)]

Characterization of parathyroid hormone/parathyroid hormone-related protein receptor and signaling in hypercalcemic Walker 256 tumor cells.

2000-07-01

[J. Endocrinol. 166 , 11-20, (2000)]

Parathyroid hormone-related protein purified from a human lung cancer cell line.

1987-07-01

[Proc. Natl. Acad. Sci. U. S. A. 84 , 5048, (1987)]

More Articles...