Synthesis and reactivity of imide-derived bisvinyl phosphates. Reactivity of 2, 6-disubstituted 1, 4-dihydropyridines

…, I Gillaizeau, A Sabatié, P Bouyssou…

Index: Mousset, Deborah; Gillaizeau, Isabelle; Sabatie, Andrea; Bouyssou, Pascal; Coudert, Gerard Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 5993 - 5999

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Citation Number: 35

Abstract

Symmetrical and unsymmetrical 2, 6-disubstituted dihydropyridines were prepared in high yields under mild conditions using the Suzuki and Stille Pd-catalyzed coupling reactions of imide-derived bisvinyl phosphates with a range of aryl, heteroaryl, and alkenyl moieties. The alkylation reaction at C-4 easily afforded original tri-and tetrasubstituted dihydropyridines. Hydrolysis of the latter under acidic condition provided efficiently either open-chain 1, 5- ...

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