Tetrahedron Letters

Direct reductive amination using triethylsilane and catalytic bismuth (III) chloride

T Matsumura, M Nakada

Index: Matsumura, Takehiko; Nakada, Masahisa Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1829 - 1834

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Citation Number: 9

Abstract

Abstract Direct reductive amination (DRA) using triethylsilane (TESH) and catalytic bismuth (III) chloride (BiCl 3) is described for the first time. The use of TESH and BiCl 3 provides easy handling, low cost, non-toxicity, and a mild Lewis acid activity, thereby meeting the demand for green and sustainable chemistry. The developed DRA is highly chemoselective and applicable to less-basic amines. The experimental results of this study revealed that the ...