Molecules 2009-01-01

1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs.

Jai Moo Shin, George Sachs, Young-moon Cho, Michael Garst

Index: Molecules 14(12) , 5247-80, (2009)

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Abstract

New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.