Annals of Nuclear Medicine 1994-08-01

Accumulation of L-[2-(F-18)]fluorophenylalanine in peri-infarct area in a patient with acute cerebral infarction.

J Hatazawa, H Itoh, E Shimosegawa, I Kanno, M Murakami, S Miura, H Iida, T Okudera, A Inugami, T Ogawa

Index: Ann. Nucl. Med. 8(3) , 213-7, (1994)

Full Text: HTML

Abstract

We studied the brain uptake of amino acid in a patient with acute cerebral infarction with L-[2-(F-18)]fluorophenylalanine and positron emission tomography. The increased accumulation of the ligand was specifically found in the peri-infarct area where oxygen metabolism was still maintained but decreased later in the 72-day follow-up period. The kinetic analysis revealed that increased accumulation was not due to increased transport from the blood to the brain but delayed washout from the brain to the blood. Although the mechanism is still unknown, abnormally high accumulation of L-[F-18]fluorophenylalanine may predict delayed neuronal changes after ischemic insults of the brain.

Related Compounds

  • 2-Fluorophenylalan...

Related Articles:

Fluorine-19 nuclear magnetic resonance spectroscopic study of fluorophenylalanine- and fluorotryptophan-labeled avian egg white lysozymes.

1994-05-03

[Biochemistry 33(17) , 5238-45, (1994)]

Positional effects of monofluorinated phenylalanines on histone acetyltransferase stability and activity.

2009-09-15

[Bioorg. Med. Chem. Lett. 19(18) , 5449-51, (2009)]

Modulating substrate specificity of histone acetyltransferase with unnatural amino acids.

2011-11-01

[Mol. Biosyst. 7(11) , 3050-5, (2011)]

Incorporation of amino acid analogs during the biosynthesis of Escherichia coli aspartate transcarbamylase.

1980-09-09

[Biochim. Biophys. Acta 615(1) , 59-69, (1980)]

Feasibility of fluorine-18-fluorophenylalanine for tumor imaging compared with carbon-11-L-methionine.

1996-02-01

[J. Nucl. Med. 37(2) , 320-5, (1996)]

More Articles...