Cellular Signalling 1998-07-01

Diadenosine polyphosphate-mediated activation of phospholipase D in isolated rat liver cells.

M Edgecombe, S P Eckersley, A G McLennan, M J Fisher

Index: Cell. Signal. 10 , 505-509, (1998)

Full Text: HTML

Abstract

Diadenosine polyphosphates (ApnAs) can, through interaction with appropriate purinoceptors, affect a range of cellular activities. Ap4A, the most prominent naturally occurring diadenosine polyphosphate, stimulates alterations in intracellular calcium homeostasis and subsequent activation of glycogen breakdown in isolated liver cells. Here we show that Ap4A, and other naturally occurring diadenosine polyphosphates, also stimulates phospholipase D (PLD) activity in isolated rat liver cells. The characteristics of Ap4A-mediated activation of PLD are similar to those for the activation of PLD by extracellular ATP. These results are discussed in the context of the relation between diadenosine polyphosphate- and adenine mononucleotide-mediated cellular signalling processes.

Related Compounds

  • A[5']P4[5']A AM...

Related Articles:

Adenine dinucleotides: a novel class of signalling molecules.

1996-12-01

[J. Auton. Pharmacol. 16 , 325-328, (1996)]

Selectivity of diadenosine polyphosphates for rat P2X receptor subunits.

1999-02-12

[Eur. J. Pharmacol. 367 , 19-123, (1999)]

Diadenosine polyphosphates in insulin-secreting cells: interaction with specific receptors and degradation.

1998-11-01

[Diabetes 47 , 1727-1734, (1998)]

P1,P4-diadenosine 5' tetraphosphate induces nitric oxide release from bovine aortic endothelial cells.

1998-05-15

[FEBS Lett. 427 , 320, (1998)]

Diadenosine polyphosphate-stimulated gluconeogenesis in isolated rat proximal tubules.

1997-04-15

[Biochem. J. 323 , 451-456, (1997)]

More Articles...